• Paratek's successful commercialization platform to advance novel therapies developed organically and through acquisitions
• Paratek adds 'final-mile' capabilities to AMR efforts

Novo Holdings, the holding and investment company responsible for managing the assets and wealth of the Novo Nordisk Foundation and Gurnet Point, a leading healthcare investment firm, closed on the acquisition of Paratek Pharmaceuticals in a transaction valued at $462 million. This is Novo Holdings' largest individual investment in antimicrobial resistance therapies to date.

With annual revenues of greater than $100 million, Paratek is one of the largest independent antibiotics companies in the world. Its lead commercial product, NUZYRA® (omadacycline), is a once-daily oral and intravenous antibiotic available in the United States for the treatment of adults with community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI). NUZYRA is the first-choice antibiotic for patients with comorbidities or suspected resistant pathogens. Paratek's specialty pharmaceutical platform enables both the development and commercialization of new drugs to bring new innovative therapies to patients.

"We are committed to maintaining Paratek's leadership in reaching patients and delivering innovative products across the globe. We look forward to supporting the continued growth of NUZYRA, and the expansion of Paratek's product portfolio, including the acquisition or licensing of other therapeutics in antibiotics and beyond," said Aleks Engel, Partner at Novo Holdings. "We are thrilled to partner with Gurnet Point, an investment firm specialized in commercial specialty pharmaceutical companies to advance Paratek's growth."

Novo Holdings' efforts to combat antimicrobial resistance (AMR) include a $165 million investment in the Replenishing and Enabling the Pipeline for Anti-Infective Resistance (REPAIR) Fund, which supports startups and early-stage companies globally, and an investment of $50 million in the AMR Action Fund supporting late-stage development companies. The REPAIR Fund has paused new investments given current antibiotics reimbursement policies; it continues to support its existing portfolio.

More than 3,500 people die each day from infections resistant to most or all antibiotics, and the number keeps increasing. Such infections are projected to kill more people than cancer by 2050. Advancements in this field are currently challenged by the lack of successful commercialization platforms, and reimbursement reforms.

The Novo Nordisk Foundation AMR efforts, embedded in its long-term strategy, include research grants for the discovery of new treatments for both human and animal infections, global monitoring of anti-microbial resistance genes, public awareness education campaigns, and advocacy for new payment reforms.