OMTX705 is a novel antibody–drug conjugate (ADC) molecule targeting fibroblast-activating protein α (FAPα). FAPα is a dimeric type II serine protease highly focal expressed in cancer-associated fibroblasts (CAF) surrounding the tumor cells and microvasculature. InxMed' studies and other publications consistently show that FAP-expressing CAFs play important roles in tumor drug resistance.

InxMed has explored and demonstrated the potential antitumoral efficacy of FAPα targeting treatment for various caner types, especially those with high incidence in Chinese population e.g., gastric cancer, esophagus cancer, etc. The company reached a collaboration with Oncomatryx, a company developing novel drugs targeting the tumor microenvironment, to co-research and develop OMTX705 preclinically and clinically, and own the commercialization rights of OMTX705 in Asia.

InxMed has been developing novel ADC drugs for hard-to-treat solid tumors since 2019. The company has demonstrated promising synergistic anticancer effects of combination therapy comprising various ADC drugs and its pivotal-trial stage drug IN10018 (Ifebemtinib), a highly potent and selective oral inhibitor of focal adhesion kinase (FAK), in animal models. InxMed is actively exploring and maximizing the potential of this treatment regimen through its own synergistic pipelines and partnering.