This development underscores the company's commitment to advancing innovative solutions that provide relief and improved quality of life for the millions of individuals who endure the burdens of chronic migraine disease.

Chronic Migraine affects approximately 2% of the global population, inflicting severe headaches, nausea, sensitivity to light, and a severely diminished quality of life, with sufferers experiencing symptoms on at least 15 days each month. For far too many, existing treatments offer little relief. In response to this unmet clinical need, ShiraTronics has engineered a fully implantable system designed to address the symptoms faced by these patients.

Rob Binney, CEO of ShiraTronics, commented, "The initiation of our Pilot Study is a momentous step forward in our mission to alleviate the suffering of those afflicted with chronic migraine. It is our belief that we have developed the world's first head-located, active implantable designed to address the unmet needs of the millions of patients who are still searching for a solution that can help improve their symptoms and quality of life. We look forward to working with our investigators to demonstrate the safety and efficacy of our novel system, as we prepare for the initiation of our IDE study in 2024."

ShiraTronics Co-Founder and Chairman of the Board, Mudit K. Jain, PhD, remarked, "The first-in-human trial phase study is a critical step in the development of this highly differential novel therapy. I am extremely proud of the efforts of the ShiraTronics team in achieving this major milestone. These efforts will ultimately help us in beating chronic migraine, a devastating disease that impacts millions globally and many people I know personally."