“Research has shown that exosomes carry important information about human health, but studying them has proven challenging,” remarked Paul R. Billings, MD, Ph.D., CEO, and Chairman of Biological Dynamics. “Providing scientists with a more reliable, rapid, and easy-to-use option for capturing exosomes is paving the way for the era of exosomes and extracellular vesicle (EV) research, allowing researchers and translational scientists in academia and industry to develop solutions to help patients live longer and healthier lives.”

Exosomes, abundant in the human body and detectable in various biological fluids, hold crucial insights into cellular communication and disease processes. However, traditional exosome isolation methods, such as ultracentrifugation and column purification, present challenges in terms of yield, purity, and efficiency. The ExoVerita platform addresses these limitations with its automated workflow, delivering samples with high yield, purity, and reproducibility. Leveraging AC Electrokinetics (ACE) technology, this innovative platform efficiently detects and recovers exosomes from biofluids like whole blood, plasma, and serum.

“Hoag’s reputation as a national center of excellence in research has been achieved by hiring the best and brightest researchers and providing them access to innovative and beneficial technologies such as Biological Dynamics’ ExoVerita Pro,” commented Michael J. Demeure, MD, Program Director of Precision Medicine and Otis Healy Family Endowed Chair in Applied Genomics at Hoag. “The opportunity to be one of the first users of ExoVerita Pro underscores our commitment to furthering clinical understanding of cancer and other diseases by employing the latest technologies to accelerate biomarker discovery.”

Following exosome enrichment with ExoVerita Pro, researchers can utilize the collected material for various experiments, including DNA amplification and sequencing, RNA analysis, and measurement of exosome protein concentration. This wealth of information holds the potential to advance drug development, facilitate disease diagnosis and prognosis, and drive numerous other applications in biomedical research.