OBI Pharma, Inc. (TPEx: 4174) today announced preclinical data demonstrating significant synergistic effects of OBI-999 and pembrolizumab (anti-PD1 mAb) in four different cancer models, as well as the potent antitumor effect of a chimeric antigen receptor T-cell (CAR T) immunotherapy targeting Globo H. These data will be presented at the American Association of Cancer Research (AACR) Annual Meeting from 14^th-19^th April, 2023 in Orlando, Florida (USA).

OBI’s Chief Scientific Officer Ming-Tain Lai, Ph.D., commented that “Our scientific data suggest OBI-999 creates a tumor microenvironment that can significantly enhance the function of pembrolizumab. This potentiated anti-tumor effect was evident in four different xenograft models (breast, gastric, colorectal, and small cell lung cancer) that expressed Globo H and PD-1. These findings support the clinical study of combination therapeutic strategies that pair OBI-999 with anti PD-1/PD-L1 cancer therapeutics. OBI has also developed the first CAR T-cell therapy (OBI-R007) targeting Globo H, which demonstrates a strong and specific anti-tumor effect on Globo H-expressing tumor cells. These encouraging results warrant further development of this novel cellular therapy.”

Title: OBI-999, an anti-Globo H antibody drug conjugate, exhibits synergistic anti-tumor effect in combination with pembrolizumab
Authors¹: Chun-Chung Wang, Chi-Huan Lu, Jhih-Jie Yang, Wan-Fen Li, Ming-Tain Lai.

Session Title: Tumor-Stromal Cell (Including Immune Cell) Interactions and Therapy Responses
Location: Section 7
Poster Board Number: 5946/7
Abstract Presentation Number: 5946
Session Date and Time: Wednesday Apr 19, 2023, 9:00 AM - 12:30 PM

Title: Globo H-targeted CAR T cell cancer immunotherapy
Authors¹: Jiann-Shiun Lai, Shiou-Ling Jian, Woan-Eng Chan, Ming-Tain Lai.

Session Title: CAR T-cell Therapy 2
Location: Section 23
Poster Board Number: 4084/4
Abstract Presentation Number: 4084
Session Date and Time: Tuesday Apr 18, 2023, 9:00 AM - 12:30 PM

¹ OBI Pharma, Inc., Taipei, Taiwan.

The e-posters will be available for browsing at the AACR Annual Meeting beginning at 12:00 PM ET on April 14, as well as on the OBI Pharma website (www.obipharma.com) beginning on April 20.