"The study outcome is excellent news in light of the unmet need for effective preventive therapies for children and adolescents living with migraine who are greatly impacted by this debilitating disease,” said Eric A. Hughes, MD, PhD, Executive Vice President, Global R&D and Chief Medical Officer, at Teva Pharmaceuticals. "The SPACE data supports our ambitions to bring the proven benefits of AJOVY to children and adolescent patients who have fewer treatment options available to them. I am pleased to see that AJOVY is continuing to demonstrate its efficacy and safety in different migraine populations, including pediatric patients.”

The SPACE data are the first Phase 3 trial evidence of safety and efficacy of an anti-CGRP monoclonal antibody for the treatment of migraine in a pediatric population. The results have particular significance given the lack of preventive migraine treatments approved for use in children and adolescent populations. Teva continues to study the impact of AJOVY(fremanezumab) in pediatric patients with chronic migraine.

Migraine is common among children, with an overall estimated prevalence of 7.7%. The prevalence increases from 5% among children aged 5 to 10 years to approximately 15% among adolescents.¹ Migraine can cause significant disability in children and adolescents, leading to absence from school, impaired educational performance and missed social activities.¹