• HMBD-002, a non-depleting, high-affinity anti-VISTA antibody, possesses key design features enabling robust anti-tumor activity in preclinical models, positioning it as a potentially important new therapy for VISTA-expressing cancers including triple-negative breast cancer and non-small cell lung cancer
• HMBD-002 is currently being assessed in a Phase 1 study to determine the recommended Phase 2 dose as a monotherapy and in combination with pembrolizumab
• Monotherapy escalation cohorts 1-4 have been completed without dose-limiting toxicities

Hummingbird Bioscience, a data-driven precision biotherapeutics company discovering and developing transformative biologic medicines for hard-to-treat diseases, today announced a Trials in Progress poster presentation for HMBD-002, a unique anti-VISTA antibody, at the American Society of Clinical Oncology (ASCO) Annual Meeting being held 2-6 June, 2023 in Chicago. The poster will summarize the Phase 1 clinical trial design for HMBD-002 (NCT05082610).

The poster describes the Phase 1, open-label, multi-center, first-in-human trial evaluating HMBD-002 as a monotherapy and in combination with Merck & Co., Inc., Rahway, NJ, USA's anti-PD-1 therapy KEYTRUDA® (pembrolizumab). The study will be conducted under a clinical trial collaboration and supply agreement with Merck & Co., Inc., Rahway, NJ, USA. Monotherapy escalation cohorts 1-4 have been completed without dose-limiting toxicities, and the trial is currently enrolling cohort 5. Combination escalation is projected to begin in the second half of 2023.

"VISTA's complex biology makes it a hard-to-drug target, yet we have shown in our preclinical studies that HMBD-002 has potent anti-tumor activity with its unique mechanism of action. In this poster at ASCO, we will display the progress that HMBD-002 has made in Phase 1 trials," said Jerome Boyd-Kirkup, Ph.D., Hummingbird Bioscience's Chief Scientific Officer. "We look forward to discussing longer-term clinical development plans and combination strategies with the wider immuno-oncology community at ASCO."

ASCO Trials In Progress Poster Details:

Poster Title: A phase 1 first-in-human clinical trial of HMBD-002, an IgG4 monoclonal antibody targeting VISTA, in advanced solid tumors
Poster Session Track: Developmental Therapeutics—Immunotherapy
Poster Session Date: June 3, 2023
Time: 8:00 AM – 11:00 AM CDT
Location: Hall A
Poster Board Number: 505b
KEYTRUDA® is a registered trademark of Merck Sharp & Dohme LLC., a subsidiary of Merck & Co., Inc., Rahway, NJ, USA.