Innovent Secures New Reimbursement Milestones for TYVYT® and BYVASDA® in China

13 December 2023 | Wednesday | News

Innovent Biologics, Inc. ("Innovent") (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high quality medicines for the treatment of oncology, metabolic, autoimmune, ophthalmology and other major diseases, announces that, the National Reimbursement Drug List (2023 Version) ("NRDL") has been updated to renew and include the seventh indication of PD-1 inhibitor TYVYT® (sintilimab injection) in negotiation list, and include the eighth indication of BYVASDA® (bevacizumab injection) in general list. The updated NRDL will officially take effect on January 1, 2024.

In the updated NDRL, TYVYT® expands its coverage to the seventh new indication for the treatment of patients with epidermal growth factor receptor (EGFR)-mutated locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) who progressed after EGFR tyrosine kinase inhibitor (TKI) therapy. Meanwhile, BYVASDA® as a combination medicine with TYVYT® for the same indication, has its eighth indication included in the NRDL. TYVYT® is globally the first and only PD-1 inhibitor approved for this indication, as well as the only PD-1 inhibitor in the NRDL for treating NSCLC post EGFR-TKI therapy. BYVASDA® is also the only bevacizumab approved and in the NRDL for treating NSCLC post EGFR-TKI therapy.

TYVYT® (sintilimab injection) is an innovative PD-1 inhibitor co-developed by Innovent and Eli Lilly and Company in China. TYVYT® has been approved and included in the NRDL for seven indications. It is also the only PD-1 inhibitor for the first-line treatment of five high-incidence cancer types in the NRDL. The updated NRDL reimbursement scope include:

  • For the treatment of relapsed or refractory classic Hodgkin's lymphoma after two lines or later of systemic chemotherapy;
  • For the first-line treatment of unresectable locally advanced or metastatic non-squamous non-small cell lung cancer lacking EGFR or ALK driver gene mutations;
  • For the treatment of patients with EGFR-mutated locally advanced or metastatic non-squamous non-small cell lung cancer who progressed after EGFR-TKI therapy (new NRDL indication);
  • For the first-line treatment of unresectable locally advanced or metastatic squamous non-small cell lung cancer;
  • For the first-line treatment of unresectable or metastatic hepatocellular carcinoma with no prior systematic treatment;
  • For the first-line treatment of unresectable locally advanced, recurrent or metastatic esophageal squamous cell carcinoma;
  • For the first-line treatment of unresectable locally advanced, recurrent or metastatic gastric or gastroesophageal junction adenocarcinoma.

Dr. Michael Yu, Founder, Chairman and CEO of Innovent, stated: "We are pleased that TYVYT® and BYVASDA® successfully expand their NRDL coverage, which will bring benefit to the broad NSCLC patients post EGFR-TKI therapy. As a company with the mission of'developing high-quality biopharmaceuticals that are affordable to ordinary people', Innovent is always committed to supporting 'Healthy China 2030' strategy and public health improvement through the development of innovative therapies. In particular, we are glad that as part of China's medical system reform, the yearly NRDL adjustment helps cover new medicines and indications in a more effective process. We hope to continue to work together with the government to improve drug affordability and accessibility, bring more high-quality drugs to patients and their families, and contribute to the ultimate goal of healthier and better life of people in China."

 

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