NetraMark Holdings Inc. (the "Company" or "NetraMark") (CSE: AIAI) (OTCQB: AINMF) (Frankfurt: PF0) a premier artificial intelligence (AI) company that is transforming clinical trials with AI powered precision analytics in the pharmaceutical industry, today announced a global agreement with Worldwide Clinical Trials ("Worldwide"), a full-service, global contract research organization (CRO). This strategic partnership introduces a new service offering for Worldwide's customers, powered by NetraMark's proprietary NetraAI platform, purpose-built to drive intelligent, patient-centric clinical trial optimization.

This agreement unites Worldwide's three decades of clinical execution excellence—recognized with 11 consecutive CRO Leadership Awards—with NetraMark's advanced NetraAI platform, an explainable AI solution designed to optimize clinical trials by uncovering hidden patient subpopulations within complex datasets. Leveraging Worldwide's global clinical operations, scientific rigor, and therapeutic expertise alongside NetraMark's proprietary machine learning platform, this collaboration enhances trial efficiency and delivers regulatory-aligned insights from even the most complex datasets.

Under this agreement, NetraMark's AI technology will initially be used for Phase 2 (neuroscience and oncology clinical trials) and select Phase 3 clinical trials conducted by Worldwide, however, broader availability will be made to all Worldwide sponsors across all therapeutic areas and trial phases. As part of the collaboration, and to streamline workflow for sponsors, NetraMark's NetraAI will be incorporated into Worldwide's offerings as a dedicated solution that underscores both companies' commitment to innovation, precision, and advancing clinical trial success.

Through this integration, Worldwide strengthens its ability to accelerate development timelines, refine patient stratification, reduce placebo response variability, and enhance overall trial power. Together, Worldwide and NetraMark aim to redefine how trials are designed and executed—enabling more informed protocol development, faster decision-making, and improved patient targeting through the use of AI.

"With this agreement, our goal is to unlock the full potential of AI to reshape the future of clinical development," said George Achilleos, CEO of NetraMark. "By integrating NetraAI with Worldwide's global clinical infrastructure, we're enabling sponsors to better understand patient response dynamics, reduce placebo variability, and improve the likelihood of regulatory success. Worldwide's new service offering will deliver a redefined standard for precision and speed in trials."

"At Worldwide, we are dedicated to partnering with sponsors for the most efficient and effective path to bring life-changing therapies to market," said Dave Bowser, Chief Operating Officer at Worldwide Clinical Trials. "By integrating NetraMark's technology into our clinical trial design, we can identify the patients most likely to drive positive trial outcomes, leading to fewer required patients per trial, reduced timelines, lower costs, and ultimately increase success rates for our sponsors. This partnership represents a significant step forward in precision medicine and patient-centric trial optimization."

Together, Worldwide and NetraMark are ushering in a new era of explainable AI in clinical research—one that is expected to enable more personalized therapies to reach patients faster and more reliably.